Outstanding Performance by a Cast in a Motion Picture
* Little Miss Sunshine – Alan Arkin, Abigail Breslin, Steve Carell, Toni Collette, Paul Dano, and Greg Kinnear
Babel – Adriana Barraza, Cate Blanchett, Gael García Bernal, Rinko Kikuchi, Brad Pitt, and Kōji Yakusho
Bobby – Harry Belafonte, Joy Bryant, Nick Cannon, Emilio Estevez, Laurence Fishburne, Brian Geraghty, Heather Graham, Anthony Hopkins, Helen Hunt, Joshua Jackson, David Krumholtz, Ashton Kutcher, Shia LaBeouf, Lindsay Lohan, William H. Macy, Svetlana Metkina, Demi Moore, Freddy Rodriguez, Martin Sheen, Christian Slater, Sharon Stone, Jacob Vargas, Mary Elizabeth Winstead, and Elijah Wood
The Departed – Anthony Anderson, Alec Baldwin, Matt Damon, Leonardo DiCaprio, Vera Farmiga, Jack Nicholson, Martin Sheen, Mark Wahlberg, and Ray Winstone
Dreamgirls – Hinton Battle, Jamie Foxx, Danny Glover, Jennifer Hudson, Beyoncé Knowles, Sharon Leal, Eddie Murphy, Keith Robinson, and Anika Noni Rose

Outstanding Performance by a Male Actor in a Leading Role
* Forest Whitaker – The Last King of Scotland as Idi Amin
Leonardo DiCaprio – Blood Diamond as Danny Archer
Ryan Gosling – Half Nelson as Dan Dunne
Peter O’Toole – Venus as Maurice
Will Smith – The Pursuit of Happyness as Chris Gardner

Outstanding Performance by a Female Actor in a Leading Role
* Helen Mirren – The Queen as Queen Elizabeth II
Penélope Cruz – Volver as Raimunda
Judi Dench – Notes on a Scandal as Barbara Covett
Meryl Streep – The Devil Wears Prada as Miranda Priestly
Kate Winslet – Little Children as Sarah Pierce

Outstanding Performance by a Male Actor in a Supporting Role
* Eddie Murphy – Dreamgirls as James “Thunder” Early
Alan Arkin – Little Miss Sunshine as Edwin Hoover
Leonardo DiCaprio – The Departed as Billy Costigan
Jackie Earle Haley – Little Children as Ronald “Ronnie” James McGorvey
Djimon Hounsou – Blood Diamond as Solomon Vandy

Outstanding Performance by a Female Actor in a Supporting Role
* Jennifer Hudson – Dreamgirls as Effie White
Adriana Barraza – Babel as Amelia
Cate Blanchett – Notes on a Scandal as Sheba Hart
Abigail Breslin – Little Miss Sunshine as Olive Hoover
Rinko Kikuchi – Babel as Cheiko Wataya