Outstanding Performance by a Cast in a Motion Picture
* Sideways – Thomas Haden Church, Paul Giamatti, Virginia Madsen, and Sandra Oh
The Aviator – Alan Alda, Alec Baldwin, Kate Beckinsale, Cate Blanchett, Leonardo DiCaprio, Ian Holm, Danny Huston, Jude Law, John C. Reilly, and Gwen Stefani
Finding Neverland – Julie Christie, Johnny Depp, Freddie Highmore, Dustin Hoffman, Radha Mitchell, Joe Prospero, Nick Roud, Luke Spill, and Kate Winslet
Hotel Rwanda – Don Cheadle, Nick Nolte, Sophie Okonedo, and Joaquin Phoenix
Million Dollar Baby – Clint Eastwood, Morgan Freeman and Hilary Swank
Ray – Aunjanue Ellis, Jamie Foxx, Terrence Howard, Regina King, Harry Lennix, Clifton Powell, Larenz Tate, and Kerry Washington

Outstanding Performance by a Male Actor in a Leading Role
* Jamie Foxx – Ray as Ray Charles
Don Cheadle – Hotel Rwanda as Paul Rusesabagina
Johnny Depp – Finding Neverland as J. M. Barrie
Leonardo DiCaprio – The Aviator as Howard Hughes
Paul Giamatti – Sideways as Miles Raymond

Outstanding Performance by a Female Actor in a Leading Role
* Hilary Swank – Million Dollar Baby as Maggie Fitzgerald
Annette Bening – Being Julia as Julia Lambert
Catalina Sandino Moreno – Maria Full of Grace as Maria Álvarez
Imelda Staunton – Vera Drake as Vera Drake
Kate Winslet – Eternal Sunshine of the Spotless Mind as Clementine Kruczynski

Outstanding Performance by a Male Actor in a Supporting Role
* Morgan Freeman – Million Dollar Baby as Eddie “Scrap-Iron” Dupris
Thomas Haden Church – Sideways as Jack Cole
Jamie Foxx – Collateral as Max Dourocher
James Garner – The Notebook as Duke
Freddie Highmore – Finding Neverland as Peter Llewelyn Davies

Outstanding Performance by a Female Actor in a Supporting Role
* Cate Blanchett – The Aviator as Katharine Hepburn
Cloris Leachman – Spanglish as Evelyn Wright
Laura Linney – Kinsey as Clara McMillen
Virginia Madsen – Sideways as Maya Randall
Sophie Okonedo – Hotel Rwanda as Tatiana Rusesabagina